R&D
Supported by science
Smartfish research and development focus on cancer, Chronic Obstructive Pulmonary Disease (COPD), pediatrics, brain health, aging, metabolism and muscle performance. We collaborate with leading scientists worldwide and have engaged in numerous clinical studies.
Clinically documented evidence includes:
- Better omega-3/omega-6 index compared to capsules
- Reduced inflammation
- Reduced fatigue
- Improved muscle function
- Faster recovery after exercise
- Improved attention
- High compliance in cancer patients
Studies related to Smartfish products
| Study# | Indication | Title | Author(s) | Registry ID | Publications | |
|---|---|---|---|---|---|---|
| SF-C002 | Cachexia, Cancer | A 12-week Double Blind, Placebo Controlled, Randomised Pilot Study Assessing Safety and Tolerability of Nutrifriend Cachexia in Patients Diagnosed with Non-Small Cell Lung Cancer (NSCLC) with Involuntary Weight Loss | Prof. M Muscarlitoli | NCT02515032 ClinicalTrials.gov | 2 Publications | #1 #2 |
| SF-K002 | Cachexia, COPD | A 12-Week, Randomised, Placebo Controlled, Multi-Centre, Parallel Group Study Assessing the Safety and Tolerability of Nutrifriend Cachexia (Non-Complete Dietary Formula) in Patients with Chronic Obstructive Pulmonary Disease (COPD) | NCT02442908 ClinicalTrials.gov | 1 Publication | #1 | |
| ISS-B001 | Brain Health | Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. | Adrian Raine, Jianghong Liu, Jill Portnoy, Joseph R. Hibbeln | NCT02016079 clinicaltrials.gov | 2 Publications | #1 #2 |
| ISS-B004 | Brain Health | Biosocial Prediction and Intervention on Childhood Aggression | Adrian Raine | NCT00842439 clinicaltrials.gov | 1 Publication | #1 |
| ISS-B008 | Brain Health | The Better Resiliency Among Veterans With Omega-3’s (BRAVO) Study: A Double Blind, Placebo-Controlled Trial of Omega-3 Fatty Acid Supplementation Among Military Veterans | Andrea Glenn, Bernadette Marriott | NCT01901887 clinicaltrials.gov | 2 Publications | #1 #2 |
| ISS-B009 | Brain Health | Effect of a Nutrition Supplement Containing Fish Oil, Whey Protein, Vitamin D, and Resveratrol, on Muscular and Cognitive Function in Older Adults | C. Moran, B. Egan | NCT02001831 clinicaltrials.gov | 2 Publications | #1 #2 |
| ISS- B011 | Brain Health | Omega-3 incorporation in US soldiers | Joseph R. Hibbeln | 1 Publication | #1 | |
| ISS- B012 | Brain Health | Omega‑3 supplementation, child antisocial behavior, and psychopathic personality: a randomized, double‑blind, placebo‑controlled, stratified, parallel group trial | Adrian Raine, Annis Fung | NCT02334098 clinicaltrials.gov | 1 Publication | #1 |
| ISS-C001 | Cancer | Body surface area-based omega-3 fatty acids supplementation strongly correlates to blood concentrations in children | L. Ljungblad et al. | NCT02134600 clinicaltrials.gov | 2 Publications | #1 #2 |
| ISS-C002 | Cancer | A randomised cross-over trial to compare erythrocyte membrane incorporation, acceptability and tolerability of omega-3 fatty acids in a drink carton formulation with an equivalent dose of omega-3 fatty acids in soft gelatin capsule form. | Henry Watson | ISRCTN18662143 isrctn.com | 1 Publication | #1 |
| ISS-G001 | General | Effects of a convenience drink fortified with n-3 fatty acids on the n-3 index | Clemens von Schacky | NCT00886704 clinicaltrials.gov | 1 Publication | #1 |
| ISS-G002 | General | A randomized controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial) | Nick Macklon, Philip Calder | 2 Publications | #1 #2 | |
| ISS-G003 | General | Determination of the glycaemic index of a clinical nutrition drink | Leatherhead Food Research | 1 Publication | #1 | |
| ISS-M001 | Metabolism | Novel Anti-inflammatory Dietary Intervention to Improve the Metabolic Phenotype of Overweight and Obese 13-18 Year Old Adolescents – Insights Into Potential Genetic Susceptibility | Helen M. Roche | NCT01665742 clinicaltrials.gov | 3 Publications | #1 #2 #3 |
| ISS-M002 | Metabolism | High fat feeding: Metabolic and molecular mechanisms for alleviation of diet-induced insulin resistance by dietary fish oils | Kevin Tipton, Sophie Louise Wardle | 2 Publications | #1 #2 | |
| IS-M003 | Metabolism | Omega-3 Fatty Acids Supplementation and Atherothrombotic Biomarkers in Type 2 Diabetes and Cardiovascular Disease. | Grzegorz Gajos | NCT02178501 clinicaltrials.gov | ||
| ISS-S001 | Sports | The Effect of Fish Oil, Vitamin D and Protein on URTI Incidence in Young Active People | Da Boit M et al. | 1 Publication | #1 | |
| ISS-S002 | Sports | Adding Fish Oil to Whey Protein, Leucine, and Carbohydrate Over a Six-Week Supplementation Period Attenuates Muscle Soreness Following Eccentric Exercise in Competitive Soccer Players | Philpott JD et al. | 2 Publications | #1 #2 | |
| ISS-S003 | Sports | Substrate Metabolism at Rest and during Steady-State Cycling Following n-3 PUFA Supplementation | Petre A et al. | 1 Publication | #1 | |
| ISS-S007 | Sports | Adding omega-3 fatty acids to a protein-based supplement during pre-season training results in reduced muscle soreness and the better maintenance of explosive power in professional Rugby Union players | Black KE et al. | 1 Publication | #1 | |
| ISS-B005 | Brain Health | Omega-3 supplementation in young offenders: a randomized, stratified, double-blind, placebo-controlled, parallel-group trial | Adrian Raine et al. | 1 Publication | #1 | |
| ISS-B010 | Brain Health | Prevention of cognitive decline and improvement of innate immunity in patients with mild cognitive impairment by omega-3 fatty acid and anti-oxidant supplementation | Milan Fiala | 4 Publications | #1 #2 #3 #4 | |
| PRE006 | Cancer | Medulloblastoma growth inhibited by LCPUFA DHA and EPA | Helena Gleismann, Per Kogner | 1 Publication | #1 | |
| PRE009 | Cancer | Effects of Nutrifriend (Smartfish), alone or in combination with chemotherapy, on tumour growth and cachexia in mice bearing the Lewis lung carcinoma | Josep M. Argilés | 2 Publications | #1 #2 | |
| PRE017 | Cancer, Cachexia | Omega‐3 and omega‐3/curcumin‐enriched fruit juices decrease tumour growth and reduce muscle wasting in tumour‐bearing mice | Silvia Busquets | 1 Publication | #1 | |
| PRE004 | Curcuminoids and ω-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon γ production | Milan Fiala | 2 Publications | #1 #2 | ||
| Omega-3 nutritional supplementation improves amyloid-beta immunity through specialized pro-resolving mediators | Bien Sagong, Jessica Leung, Milan Fiala, Rachel Rubattino, Sam Famenini | 1 Publication | #1 | |||
| Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid- Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment | Jesmond Dalli, Milan Fiala, Niccolo Terrando | 1 Publication | #1 |